U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol

Propofol is used widely for intravenous anaesthesia during surgery and sedation in critical care. There no method currently to assay the concentration of propofol plasma real time. The ability do so would significantly improve patient safety. A novel approach consisting Beta-Cyclodextrin (β−CD) assisted propofol-imprinting onto TiO2 films deposited on U-shaped optical fibres was measurement aqueous solutions. sensing mechanism based refractive index change induced by removing binding from β−CD/propofol complex embedded films, respectively. Complexation between host guest (propofol) confirmed nuclear magnetic resonance (NMR) spectroscopy, UV-Vis Attenuated Total Reflectance- Fourier-transform infrared spectroscopy (FTIR). developed sensors presented Langmuir adsorption mM range lowest detected 0.69 μM= 0.12 μg/ml. can be replicated other compounds biomedical applications such as vitamins, hormones, or drugs.